Finally, our sample did not have enough cases of substance use disorders to look beyond cannabis and alcohol use. However, the relationships among neuroticism, internalizing psychopathology, and substance use disorders may be important for understanding comorbidity. Neuroticism is related to some forms of alcohol dependence, but other forms of alcohol dependence may be more related to antisocial personality (Sher et al., 2005; Sher & Trull, 1994). Thus, future studies that incorporate more aspects of personality, including personality disorders, may be better able to model the relationships among personality traits and substance use disorders.