Association results presented in this manuscript take into account the posterior probability on each imputed genotype. To combine results, we used a weighted Z-score method: zw=zi×Ni∕Ntot zw is the weighted Z score from which the meta-analytic two-tailed P value is calculated, zi is the Z score from study i (calculated as the cumulative normal probability density for the corresponding one-tailed P value, adjusted if needed by subtracting the P value from one when the direction of the effect is reversed), Ni is the sample size of study i and Ntot is the total sample size. In total, we combined association results at 2,260,683 autosomal SNPs in 15,821 individuals (DGI, n = 2,978; FUSION, n = 2,371; KORA, n = 1,644; NHS, n = 2,286; PLCO, n = 2,244; SardiNIA, n = 4,305). The I2 statistic40 and Cochran’s Q test were used to assess heterogeneity.
