Chunk #17 — DIMENSIONS OF PSYCHOPATHOLOGY IN NEUROLEPTIC-NAÏVE PATIENTS WITH RECENT-ONSET SCHIZOPHRENIA — Predictive validity of neurodevelopmental markers (MPAs and NSS) as a composite endophenotype of schizophrenia and its relationship with symptom dimensions
Schizophrenia is conceptualized as a neurodevelopmental disorder[43] with manifest anomalies of peripheral ectodermal structures that are formed simultaneously with the cerebral cortex during intra-uterine development. The presence of such MPAs is suggested to be a very important indirect evidence for cerebral maldevelopment in schizophrenia.[44] The generalized neurodevelopmental deficit underlying schizophrenia may also be manifested as subtle, nonspecific, and non-localizable neurological signs, referred to as NSS.[45]
