Data are expressed as mean (± s.e.m.) unless otherwise indicated and statistical analyses, as detailed in Supplementary Information, were performed using SPSS (v22), GraphPad Prism (v6), and PLINK (v1.06)19. Sample sizes for animal studies were determined based on experience of effects typically encountered in behavioral and molecular studies while human studies were based on previously published datasets. For details, see Supplementary Information.
