Association studies were performed to understand the relationship between CREM and traits related to impulsivity. All participants provided informed consent and studies were conducted in accordance with institutional approval (Queens College, CUNY, for preschool and adolescent ADHD studies; Wayne State University for post mortem opiate use studies; Semmelweis University, Hungary, for post mortem heroin use studies; and Icahn School of Medicine at Mount Sinai, New York, for cannabis dependence studies). For details and demographics, see Supplementary Information.