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Chunk #37 — Results

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Problems and pit-falls in testing for G × E and epistasis in candidate gene studies of human behavior.
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In this example of complementary gene interaction, transformation redresses the balance somewhat by reducing the support for G × E but still yields markedly inflated type I error rates. A test with variable item difficulties (Table 7) recovers the right qualitative answer for the genetic architecture. Again, dichotomizing any of the scales makes it all but impossible to estimate any parameters of the full model with sufficient precision to resolve individual components of the model (results not tabulated).