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Chunk #44 — Summary and Discussion

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The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies.
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As described in the previous sections and listed in Table 1, it is very clear that CSD measures have shown remarkable advantages compared to scalp potentials in terms of topographic patterns, strength of activations, and more reliable spatial localization of neuroelectric activity during resting EEG as well as during cognitive tasks by elucidating subtle differences across and within several neuropsychiatric conditions, such as, alcoholism, schizophrenia, depression, anxiety, CD, ASD, ADHD, epilepsy, and space-occupying brain lesions. CSD has also proven to successfully differentiate individuals at high risk to develop certain clinical conditions, more successfully in alcoholism (Ramachandran et al., 1996; Rodriguez Holguin et al., 1999b; Hada et al., 2001) and also in psychosis (Kayser et al., 2014) from that of healthy controls. Further, presence and absence of a specific symptom (e.g., hallucination) within a particular diagnostic category or domain (e.g., psychosis) could also be differentiated using the CSD method, namely CSD measure could elicit differences in activation patterns between schizophrenic subjects with and without hallucinations (Kayser et al., 2012). Additionally, CSD has been found useful to understand neuroelectric activations in patients