little interference to facilitate reversal plasticity. Proactive interference, previous learning disrupting later learning, is minimized by forebrain acetylcholine. Human fMRI shows basal forebrain activation during resolution of proactive interference tasks in normal individuals but not in alcoholics (De Rosa et al., 2004). Damage to the basal forebrain could alter an individual's ability to resolve proactive interference, altering reversal learning ability. These findings, taken together with our findings suggest persistent basal forebrain dysfunction following adolescent binge drinking that continues through life.
