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Chunk #30 — 3. Results — 3.3. Correlations among the Top Significant Variables

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Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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Correlations among the top significant variables are shown in Figure 6. It was found that BIS impulsivity scores had highly significant negative correlations (p < 0.01) with visual memory performance (i.e., memory span and total correct scores of the forward condition of the VST), indicating that individuals with higher impulsivity showed poorer visual memory performance. Interestingly, of the six FC variables that showed significant correlations (p < 0.05) with one or more BIS scores, three DMN connections (s1–s5/L.PCC–L.IPL, s2–s5/R.PCC–L.IPL, and s3–s7/L.ACC–L.PFC) were positively correlated with impulsivity as well as having hyperconnectivity in AUD (Figure 5), whereas the other three DMN connections (s1–s4/L.PCC–R.ACC, s3–s9/L.ACC–L.LTC, and s6–s9/R.IPL–L.LTC) were negatively correlated with impulsivity (p < 0.05) as well as having hypoconnectivity in AUD (Figure 5), thus linking altered FC and higher impulsivity with AUD status. Furthermore, of the four FC variables that had significant correlations with two visual memory scores (i.e., the memory span and total correct scores of the forward condition of the VST), three of them (s1–s4/L.PCC–R.ACC, s2–s4/R.PCC–R.ACC, and s4–s9/R.ACC–L.LTC) showed significant positive correlations (p = 0.05–0.01) and one of the