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Chunk #35 — Discussion

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Discovery of novel heart rate-associated loci using the Exome Chip.
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The conditional analysis results provided one new, unreported association at a previously reported HR locus, KIAA1755 (rs41282820; c.1528C>T or c.1528C>A; p. Arg510Ter, a loss of function variant). KIAA1755 is predicted to encode an uncharacterized protein, and is only characterized at the transcriptional level. The transcript is highly expressed in the brain and nerves, and it is also expressed in the heart.