Detailed demographic information, including sample sizes, ethnicity and diagnosis of the 18 cohorts with other neuropsychiatric disorders, is shown in Supplemental Table S1 or is available in dbGaP database (http://www.ncbi.nlm.nih.gov/gap). These subjects were genotyped on different Illumina or Affymetric microarray beadchip platforms. All subjects gave written informed consent to participating in protocols approved by the relevant institutional review boards (IRBs). All subjects were de-identified in this study that was approved by Yale IRB.