After we identified a significant risk genomic region in the European-American discovery cohort, we imputed that entire region (1.5 Mb at Chr5: 61,708,573-63,257,546 from the transcript start site (TSS) of IPO11 to the TSS of HTR1A) in all samples of 21 cohorts using the same strategy as previously (Zuo et al., 2012). Rare variants with minor allele frequencies (MAF) < 0.05 were excluded.
