For the genetic analysis, our a priori hypothesis focused on the CHRNB3 gene and its possible association with “dizziness,” based on the work published by Zeiger et al. (2008). All statistical analyses were completed using Statistical Analysis Software (SAS) v.9.1. Haplotype blocks and linkage disequilibrium were examined using Haploview v4.1 (Barrett et al., 2005). We conducted a general linear regression analysis for each of the SNPs in the CHRNB3 gene (17), where the “dizziness” score (residual score for 1–4 responses after regression of case status) was the dependent variable predicted by the SNP, with age and sex as covariates.
