Regarding neurochemical correlates with alcoholism, as far as we can tell all of the studies examining innate neurochemical differences within these rat line-pairs (Table 3) were conducted in male rats. Therefore, sex-differences in these neurochemical substrates have not been examined thus far, which leaves a large gap in the literature. Also, of the four lines described in Table 3, the AA vs. ANA rat line-pair has had the most research conducted on innate neurochemical differences. The P vs. NP line-pair is next in the number of published studies on innate neurochemical differences followed closely by the sP vs. sNP line-pair. Finally, the HAD1 vs. LAD1 and HAD2 vs. LAD2 line-pairs have had relatively little published compared with these other three rat line-pairs. Moreover, at least half of the research published on the HAD vs. LAD rat lines does not explicitly state the replicate line-pair examined, which has forced us to state HAD vs. LAD differences in many instances rather than the preferred HAD1 vs. LAD1 or HAD2 vs. LAD2 distinctions. Also, in general only the DA, NE, 5-HT and opioid
