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Chunk #14 — RESULTS — Relationship between IADLs, BADLs, and CDR‐SB

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Assessing the clinical meaningfulness of slowing CDR-SB progression with disease-modifying therapies for Alzheimer's disease.
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For IADLs at baseline, most CDR 0.5 participants (95%) were independent, whereas a minority of CDR 1 participants (40%) were independent (Table 1). Nearly all participants were independent in BADLs at baseline. We individually modeled the four individual components of IADLs (paying bills, driving, remembering medications/appointments, and meal preparation) and estimated the level of independence for each of the four items as a function of the CDR‐SB score (Figure 1A). There were differences between the four components in the estimated CDR‐SB score at which an estimated 50% of participants were dependent. For example, participants remained independent in meal preparation and remembering medication/appointments at a higher CDR‐SB as compared to paying bills and driving.