We next examined the relationship between CDR‐SB and loss of independence in ADLs. Independence in IADLs, as defined by loss of independence with three or more of the four IADLs components, occurred at CDR‐SB = 4.5 for 50% of individuals (Figure 1B, based on N = 352 visits from N = 127 participants with independent IADLs at baseline). Loss of independence in BADLs, as defined by requiring assistance with personal care, occurred at CDR‐SB = 11.5 for 50% of individuals (based on N = 884 visits from N = 285 participants with independent BADLs at baseline). Both threshholds had very high concordance, highlighting the strong relationship between CDR and ADLs. For BADLs, 93% of participant visits scored as CDR‐SB <4.5 were also scored as independent in IADLs and 87% of visits with CDR >4.5 did not have independence in IADLs (47% of those with CDR‐SB = 4.5 had independence in IADLs). Similarly, 97% of participant visits scored as CDR‐SB <11.5 were also scored as independent in BADLs and 85% of observed visits with CDR‐SB >11.5 did not have independence in BADLs (no participants scored CDR‐SB = 11.5).
