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Chunk #16 — RESULTS — Estimating remaining time of independence

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Assessing the clinical meaningfulness of slowing CDR-SB progression with disease-modifying therapies for Alzheimer's disease.
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The first step in estimating remaining time of independence in ADLs was to model progression of CDR‐SB over time (change from baseline CDR‐SB, Table 1). Overall, the average annual CDR‐SB increase was 1.30 (95% CI 1.13–1.48). When modeled as a function of baseline CDR, CDR‐SB increased by 1.05/year (95% CI 0.85–1.26) for individuals with a baseline CDR 0.5 and by 1.85/year (95% CI 1.70–2.00) for individuals with a baseline CDR 1. Of note, although different slopes are estimated for the different baseline CDR global values, the model assumes a linear increase in CDR‐SB over time.