Positron emission tomography imaging has shown that there is reduced activation of the medial prefrontal cortex in high versus low lethality suicide attempters,61 a difference accentuated by fenfluramine, a serotonergic agonist. This is consistent with the reproduced finding that the prolactin response to fenfluramine is decreased in individuals with a past history of SB.62, 63 In addition, activity in these brain regions was associated with intent and lethality of a previous suicidal act.61 See Jollant et al.64 for a more complete review of neuroimaging findings.
