Previous studies in other populations combining neuroimaging and genetics suggest that the brain regions involved in vulnerability to SB are modulated by genetic polymorphisms previously associated with SB. For instance, the 5HTTLPR variant known to regulate expression of the 5HT transporter was found to modulate activation of the medial prefrontal cortex and amygdala during the resting state,65 and the amygdala or amygdala–prefrontal coupling during aversive stimulation.66, 67
