The present report is based on an analysis of data for 209 third generation offspring who are part of an ongoing family study that selected families through their parents’ generation. The offspring were evaluated during childhood and adolescence at approximately annual intervals and biennially during young adulthood. A total of 99 High-Risk offspring from maternal multiplex families were studied (HR; 55 females and 44 males) along with 110 Low-Risk offspring (LR; 50 females and 60 males). The study has ongoing approval from the University of Pittsburgh Institutional Review Board. All participants provided consent at each visit. Children provided assent with parental consent.
