Figures 2A and B show that the strength and pattern of ventral striatal correlations were quite similar between the male and female offspring. In contrast, the analyses revealed a different profile between the sexes in the dorsal striatum (Fig. 2C and D), with a number of the associations being stronger in females. In particular, glutamate receptor subunit genes in the dorsal striatum, especially Grin2A, had greater positive correlations with other NMDA and AMPA receptor subunit genes in females than in males. In males the correlations of Grin2A with other genes ranged from r=0.15 (p=0.603) to 0.48 (p=0.477) whereas in females the correlations were stronger, ranging from 0.69 (p=0.005) to 0.78 (p=0.001). Intriguingly, relationships between the mRNA levels of Cnr1 and other genes were also highly significant in females (Cnr1-Grin1: r=0.61, p=0.016; Cnr1-Grin2B, r=0.64, p=0.01; Cnr1-Gria1, r=0.66, p=0.007; Cnr1-Gria2, r=0.67, p=0.006; Cnr1-Dlg4, r=0.73, p=0.002; Cnr1-Dlgap3, r=0.59, p=0.021) but not or less so in males.
