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Chunk #15 — 3. Results — 3.2 Sex-related profiles in the relationships between the mRNA levels of genes relevant to synaptic plasticity

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Cross-generational THC exposure alters the developmental sensitivity of ventral and dorsal striatal gene expression in male and female offspring.
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The observed mRNA level abnormalities raised questions about potential functional associations between the various genes in the different striatal region of each sex. As such, we explored co-expression patterns between genes using pairwise correlation analyses in the combined dataset of THC and vehicle animals. We focused on adulthood given the fact that our adult cohort had a larger sample size (N=8 in each treatment group and sex) and that most of our previous work focused on identifying molecular and behavioral alterations in adult offspring with parental THC exposure (Szutorisz et al., 2014; Watson et al., 2015).