Chunk #14 — 3. Results — 3.1. Cross-generational THC exposure leads to developmental gene expression abnormalities in the striatum of male and female offspring
Considering the significant contributions of sex-related alterations, Table 3 was created to provide an overview regarding the directionality of THC-related change. The data clearly emphasizes an intriguing developmental shift from ventral to dorsal striatal abnormalities in males and females between adolescence and adulthood. Adolescent females already showed an “adult-like” pattern with less ventral striatal abnormalities detectable and a tendency for THC-related down-regulation compared with their male littermates. This was interesting considering that at the adolescent developmental time point of our analysis (PND35), female rats are typically more advanced in puberty than males (Schneider, 2008).
