Chunk #13 — 3. Results — 3.1. Cross-generational THC exposure leads to developmental gene expression abnormalities in the striatum of male and female offspring
In the adult ventral striatum, a significant main effect of THC was detected for Grin2A (p=0.02), with parental THC exposure leading to decreased expression (Table 1). A main sex effect was also evident for Grin1, Grin2A, Grin2B, Gria1, Gria2, Dlg4 but no treatment and sex interactions were identified. A prominent feature of the adult dorsal striatal impairments noted for the genes studied was the impact of parental THC exposure (Table 2). Altered gene expression (reduced by THC) included Cnr1 (p=0.04), Grin1 (p=0.003), Grin2A (p=0.001), Grin2B (p=0.014), Gria1 (p=0.008), Gria2 (p=0.001), Dlg4 (p=0.02), and Dlgap3 (p=0.004). No significant interactions were detected between THC and sex, but the analysis indicated main sex effects for multiple genes [Cnr1 (p=0.0008), Grin2A (p<0.0001), Dlg4 (p<0.0001), and Dlgap3 (p<0.0001)] (Table 2). Females expressed either lower (Grin2A, Dlg4) or higher (Dlgap3) levels than males.
