Chunk #36 — Methods and results — Testing for significance of gene-environment interaction effects using the reparameterized equation

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Testing for measured gene-environment interaction: problems with the use of cross-product terms and a regression model reparameterization solution.

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Generally, to test for any interaction effect means that one of the coefficients A, B or C is different from 0 (i.e., the slope difference between two of the genotypic groups is significant). In this case we can use the smallest of PA, PB and PC as the general interaction p value.