Chunk #35 — Methods and results — Testing for significance of gene-environment interaction effects using the reparameterized equation

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Testing for measured gene-environment interaction: problems with the use of cross-product terms and a regression model reparameterization solution.

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Note also that C = A + B. Accordingly, we have three hypotheses and corresponding p-values (4)TestA:H0:A=0,H1:A≠0,p−valuePA,TestB:H0:B=0,H1:B≠0,p−valuePB,TestC:H0:C=0,H1:C≠0,p−valuePC.