We used the promoter (H3K27ac, H3K4me3), enhancer (ATAC-Seq), and promoter–enhancer interactome (PLAC-Seq) data for four specific cell types of brain (microglia, neuron, astrocytes, and oligodendrocytes) to elucidate the functional significance of co-localized SNPs57. The location of each epigenetic mark was intersected with the location of variants prioritized by SMR analysis. UCSC browser (ttps://genome.ucsc.edu/) was used to visualize the overlap of epigenetic markers with SNPs at 17q.21.31 [MAPT] and 11p11.2 [SPI1] loci.
