paperKB
coga / coga-kb
Help
Sign in

Chunk #44 — Methods — Summary Statistics — UKB GWAS

Source
Resource profile and user guide of the Polygenic Index Repository.
Embedded
yes

Text

Supplementary Table 5 lists all UKB phenotypes for which we ran GWASs. Before running the GWASs, we filtered out poor-quality genotypes: (i) samples identified as putatively carrying sex-chromosome configurations that are neither XX nor XY, (ii) samples identified as outliers in heterozygosity and missingness rates, (iii) samples whose sex inferred from sex chromosomes does not match self-reported gender, and (iv) samples with missing sex, birth year, genotyping batch, or PC information. We also restricted the sample to individuals we will refer to as of “European ancestries,” defined as the first genetic PC provided by UKB being greater than 0 and individual self-reporting to be of “British”, “Irish”, or “Any other white background.”