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Chunk #68 — Methods — Constructing Repository PGIs — Genotyping and Imputation in Repository Cohorts

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Resource profile and user guide of the Polygenic Index Repository.
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Genotyping was performed using a range of commercially available arrays. Cohorts were encouraged to upload genotypes imputed against the 1000 Genomes Phase 376 or HRC57 imputation panels. Some cohorts provided only genotyped SNPs or data imputed against an older panel. In those cases, we performed the imputation against the HRC reference panel (version 1.1) using the Michigan Imputation Server77. Supplementary Table 11 provides study-specific details on the genotyping arrays, pre-imputation quality control filters, imputation software used, and reference samples.