smokers and 3.1% in former smokers. The p values were attenuated in the ICGN family-based population following adjustment for age, sex, pack-years of smoking and center but remained highly significant (Table 2). We identified a SNP by pack-years interaction (p = 0.0037 for rs8034191), however no significant SNP by current smoking status interaction (p = 0.85) was detected in the ICGN population.
