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Chunk #15 — Results — GREX associations are consistent with functional validation

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Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.
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To understand the impact of altered expression of our 67 SCZ-associated genes, we performed an in-silico analysis of mouse mutants, by collating large, publicly available mouse databases49-52. We identified mutant mouse lines lacking expression of 37/67 of our SCZ-associated genes, and obtained 5,333 phenotypic data points relating to these lines, including 1,170 related to behavioral, neurological or craniofacial phenotypes. Twenty-five out of 37 genes were associated with at least one behavioral, neurological or related phenotype (Supplementary Table 3).