We carried out two tests to assess the rate of phenotypic abnormalities in SCZ-associated mouse lines. First, we compared the proportion of SCZ-gene lines with phenotypic abnormalities to the ‘baseline’ proportion across all mouse lines for which we had available data. SCZ-associated lines were significantly more likely to display any phenotype (paired t-test, p = 0.009647). Next, we repeated this analysis for genes identified in S-PrediXcan analyses of 66 publicly available GWAS datasets. SCZ mouse lines had higher levels of nervous system (40.5% vs. 37.6%), behavioral (35.1% vs. 32.0%), and eye/vision phenotypes (29.7% vs. 17.0%) compared to these ‘baseline’ GWAS comparisons. SCZ mouse lines also had higher rates of embryonic phenotypes, usually indicative of homozygous lethality or mutations incompatible with life (27.0% vs. 21.1%).
