We assessed expression of our SCZ-associated genes throughout development using BRAINSPAN53. Data were partitioned into eight developmental stages (four pre-natal, four post-natal), and four brain regions32,53 (Figure 3a). SCZ-associated genes were significantly co-expressed, in both pre-natal and post-natal development and in all four brain regions, based on local connectedness54 (Figure 3b), global connectedness54 (i.e., average path length between genes, Supplementary Figure 5), and network density (i.e., number of edges, Supplementary Figure 6). Examining pairwise gene expression correlation (Supplementary Figure 7) and gene co-expression networks (Supplementary Figure 8) for each spatiotemporal point indicated that the same genes do not drive this co-expression pattern throughout development; rather, it appears that separate groups of genes drive early pre-natal, late pre-natal and post-natal clustering.
