h bout, or four 1 h bouts during the dark cycle, usually for 5 days a week for 3–4 weeks (Bell et al., 2014; McBride et al., 2013; McClintick et al., 2015). These protocols can achieve high blood alcohol levels (BEC); using voluntary consumption methods, P rats reached BEC of 40–90 mg/dl (8.7 – 19.5 mM) (Bell et al., 2014); with ethanol vapor chambers BEC of 175–325 mg/dl (38 – 70 mM) can be achieved (Jury et al., 2017; Melendez, 2011).
