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Chunk #21 — Results — Publication Bias Analyses

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Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.
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P value was 0.0001, and Kendall's tau P value was 0.04; the trim and fill analysis showed that there might be six potential missing studies, and the adjusted effect size was 2.17(1.93, 2.43) under the random effects model. For the dominant model, in the Asian samples the P(T) was 0.032, there might be four potential missing studies, and the adjusted effect size was 2.24(1.96, 2.57). However, it should be noted that all the three adjusted values of effect size were larger than the corresponding observed values, which implied stronger associations in the adjusted studies compared with the observed studies. That is, the imputed missing studies were positive.