Chunk #9 — Adenosine, Receptors and Functions in the CNS

Source

Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications.

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Both A1 and A2A receptors are also expressed in endothelial cells of the primary human brain, suggesting that modulation of these receptors can alter blood–brain barrier (BBB) and result in abnormal brain permeability that could interfere with drug delivery into the CNS.74