Finally, these data underscore differences in performance of the SRE across generations and sexes. Consistent with a prior report (Schuckit et al., 2019b), in Tables 1, 2, and 5 the zero-order correlations between SRE values and maximum drinks or numbers of AUD criteria were usually higher in offspring. An earlier publication speculated that some of this generational pattern of results might relate to a greater vulnerability to positive alcohol expectancies in the younger generation (Schuckit et al., 2019a), a finding that requires replication. The sex differences are likely to reflect the fact that women require fewer drinks for effects relating to their higher BACs per drink as a consequence of their average lower weight, lower percent body water, and slower alcohol metabolism (Cynders et al., 2016; Eng et al., 2005; Schuckit et al., 2012). Such differences might influence the correlations of SRE values to alcohol outcomes in analyses that do not control for sex.
