The Study of Addictions: Genes and Environment (SAGE) includes 3988 individuals ascertained from 3 study sources: the Collaborative Study of the Genetics of Alcoholism (N=1410; Begleiter et al., 1995; Reich et al., 1998), the Collaborative Study of the Genetics of Nicotine Dependence (N=1406; Bierut et al., 2007) and the Family Study of Cocaine Dependence (N=1172; Bierut et al., 2008). Further details regarding the study are available elsewhere (Bierut et al., 2010). The study includes substantial numbers of individuals who have used cannabis and experience problem use. For these analyses, data on 3053 (77% of the sample) individuals reporting a history of ever using cannabis were used.
