Conversely, for individuals matching the guidelines for established risk factors (Fig. 5b), there were notable differences in IS incidence for individuals in the top (1%) compared with the bottom (1%) of the metaGRS; with 2.8% (95% CI 1.7–3.9%) vs. 1.2% (95% CI 0.7–1.7%) in males and 1.7% (95% CI 1.0–2.4%) vs. 0.7% (95% CI 0.4–1.0%) in females, respectively, by age 75. These results further indicate that the metaGRS captures residual risk of stroke not quantified by existing risk factors.
