In this study, we developed a genomic risk score for IS based on GWAS summary statistics for 19 stroke and stroke-related traits. We quantify the predictive power of the IS metaGRS by comparing it to previously published genetic scores and measures of established non-genetic risk factors, and demonstrate its added value in combination with established risk factors and in the context of current guidelines for primary stroke prevention. While GRS for stroke are not yet at the level necessary for clinical translation, our analyses constitute several significant advances.
