Consistent with our previous findings for AD on chromosome 4, the region that was associated with MaxDrinks also extended to the locus LOC100507053. Five SNPs at LOC100507053, which is in the same genomic region as the ADH cluster, were significant only in the AA sample (Figure 3B). This uncharacterized RNA gene was previously associated with AD symptom count (Gelernter et al., 2014). Three of these five significant SNPs were associated in the present study but were not observed in our previous AD GWAS. We also previously found that 11 SNPs in ADH1C were associated with AD symptom count (Gelernter et al., 2014). None of those SNPs were associated with MaxDrinks, though there was one marginally significant SNP in the AA population in the combined Yale-UPenn and SAGE samples (rs34009511, p=8.1x10-8).
