SNP, rs1789882 (Ile12520Ile) (MAF=0.23, p=2.1 x 10-9, β=-0.14), and one intronic SNP, rs1693457 (MAF=0.23; p=4.2 x 10-9, β=-0.14), were significant in AAs but were monomorphic in EAs. All four SNPs in ADH1B were previously shown to be significantly associated with AD. These findings confirm the contribution of ADH1B to the development of alcohol-related pathophysiological phenotypes. Our prior GWAS used AD criteria and diagnosis as traits, however, MaxDrinks is not among the AD diagnostic criteria. Regional Manhattan plots on chromosome 4 close to AHD cluster are showed in Fig 3A for EAs and in Fig 3B for AAs.
