The peak GWAS hits were from the ADH1B locus. As expected, the functional SNP rs1229984 (A>G Arg48His) showed the strongest association with MaxDrinks in the EAs from combined Yale-Upenn and SAGE samples (minor allele frequency, MAF=0.06, p=5.96 x 10-15, β=-0.26) (Table 2, Figures 1A, 1B). This SNP remained highly significant after adjusting for BMI (p=4.27 x 10-12). Individuals with His48 allele reported less number of maximum drinks within 24 hours than homozygote Arg48 individuals (Figure 4A). This SNP is minimally informative in AA samples. However, another functional SNP in ADH1B, rs2066702, was strongly associated with MaxDrinks in the AAs from the combination of Yale-UPenn and SAGE samples (MAF=0.19, p=2.5 x 10-10, β=-0.16, p=1.89 x 10-8 adjusting for BMI) (Figures 2A, 2B). Individuals carrying Cys allele reported less number of maximum drinks (Figure 4B). Two other SNPs in ADH1B, one synonymous SNP, rs1789882 (Ile12520Ile) (MAF=0.23, p=2.1 x 10-9, β=-0.14), and one intronic SNP, rs1693457 (MAF=0.23; p=4.2 x 10-9, β=-0.14), were significant in AAs but were monomorphic in EAs. All four SNPs in ADH1B were previously shown to be significantly associated with
