For this analysis we relaxed the MAGMA FDR threshold from 5 to 10%, which produced a set of 17 genes; 3 of these 17 genes (KDM4A, PTPRF, CACNA2D2) had a total of 464 interactions with drugs belonging to ATC drug classes (see Fig. 2 and Supplementary Table 10). The most abundant second-level ATC classifications identified were antibacterials for systemic use, psycholeptics, and gynecological antiinfectives and antiseptics. Interactions with KDM4A included both dopamine agonists and agents, as well as adrenergic agents, drugs used in alcohol dependence such as disulfiram, opioid anesthetics, such as sufentanil citrate, and antidepressants.
