Chunk #26 — Results — Genome-wide association analysis, biological annotation, gene, and transcriptome-based association analyses

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Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

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Lastly, gene-set analysis in MAGMA identified one significant gene set, which is involved in the activation of Phospholipase D (Supplementary Table 9). Intriguingly, activation of Phospholipase D2 modulates agonist-induced µ-opioid receptor desensitization and resensitization [41].