Chunk #25 — Results — Genome-wide association analysis, biological annotation, gene, and transcriptome-based association analyses

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Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

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In addition to the GWAS, we performed several gene-based analyses. KDM4A was implicated by both MAGMA (FDR 5%) and H-MAGMA (Supplementary Tables 6 and 7). PTPRF was implicated by H-MAGMA (Supplementary Table 7). None of these analyses identified LRRIQ3. H-MAGMA analysis also identified ARTN (previously showing a nominal association with tea consumption in UKB; Supplementary Table 7). S-MultiXcan did not identify any significant genes (Supplementary Table 8).