measured by qPCR. Data are mean or standard deviation (Stdev), n = 5–6 mice/group*p < 0.05 and significant p values are offset from non-significant valuesTable 4Gene expression profile of the hippocampusHippocampusPFEtOHPF vs EtOHEtOH + 6wk CVCEtOH vs 6 weeksEtOH + 3wk CVCEtOH vs 3 weeks, p valueMeanStdevMeanStdevp valueMeanStdevp valueMeanStdevNanostring C1qa1.0590.3511.0490.4110.9660.8510.2650.3440.6700.2350.078 C1qb1.0090.1501.4620.147*< 0.0011.7820.4590.1341.5630.2650.431 Ccl111.1560.74314.5212.660.0734.6263.5100.0953.3333.0570.062 Daxx1.0290.2610.8210.3980.3100.7330.2170.6450.6220.2530.327 Gnas1.0170.2080.5850.306*0.0170.6130.1000.8340.4920.2260.563 Hmgn11.0170.2131.4820.333*0.0161.3020.2130.2911.4850.6450.993 Hspb11.0440.3221.3570.4320.1851.2740.2780.7031.0130.2830.134 Il231.8041.91110.625.981*< 0.013.7804.233*0.0453.0993.019*0.020 Itgb21.2250.7490.6320.2540.0971.3400.601*0.0240.9130.4710.227 Map3k91.0730.4142.2981.4280.0711.5330.4430.2391.0790.2930.068 Mapk11.0870.4091.0330.2420.7851.0410.5700.9760.8870.2510.329 Mef2a1.0220.2331.6360.7020.0701.5770.1830.8461.7840.3490.653 Myd881.0290.2631.3790.2850.0521.2220.2720.3541.0220.209*0.033 Plcb11.0870.4381.6850.307*0.0211.7240.3280.8371.7420.1910.708 Tgfβ11.0390.3020.9460.3440.6300.9820.3420.8580.4880.312*0.036Proinflammatory Tnfα1.2460.6512.2061.9110.2911.4900.6650.4071.3831.2140.394 Il1β2.3200.7572.5871.7070.8531.6220.8110.2391.5700.8660.222 Il171.0690.6961.0170.5340.8591.6520.7450.1211.2130.7690.620 Tlr41.0470.2361.7720.8560.0831.7730.8910.9991.4960.7280.562 Cox21.0070.1531.0110.1680.9701.2750.231*0.0471.3250.257*0.031 Ym11.0930.41222.4013.11*< 0.018.8499.1920.0848.1837.048*0.041CCR2/5 network Ccl21.0510.6333.9262.837*0.0343.8582.1620.9631.4511.0330.072 Ccl31.3010.8216.7133.069*< 0.012.1881.338*< 0.012.7372.238*0.035 Ccr21.0240.40211.676.247*0.0103.9583.253*0.0352.9552.310*< 0.01 Ccr51.0240.2233.4331.685*< 0.011.6590.404*0.0312.2670.7330.151Gene expression was measured by qPCR. Data are mean or standard deviation (Stdev), n = 5–6 mice/group*p < 0.05 and significant p values are offset from non-significant valuesTable 5Gene expression profile of the cerebellumCerebellumPFEtOHPF vs EtOHEtOH + 6wk CVCEtOH vs 6 weeksEtOH + 3wk CVCEtOH vs 3 weeks, p valueMeanStdevMeanStdevp valueMeanStdevp valueMeanStdevNanostring C1qa1.0790.472.7881.243*0.0101.9420.8720.2021.2660.786*0.030 C1qb1.0120.1611.0170.3970.9760.7730.2750.2441.1650.2640.466 Ccl111.0430.32637.2236.990.06016.7026.980.3156.68212.750.119 Daxx1.0150.1820.9720.2650.7501.1320.5240.5190.7040.2140.083 Gnas1.0140.1980.7130.4010.1300.8420.2690.5280.6110.1600.577 Hmgn11.1960.9772.3021.3530.1361.5310.4860.2191.1831.1540.155 Hspb11.1670.7332.9951.489*0.0221.9160.7240.1411.0070.683*0.014 Il231.2771.1102.4491.7910.2032.2780.8490.8361.0321.0110.122 Itgb21.0340.2862.1501.8300.1691.0240.8680.2211.5011.0000.516 Map3k91.2200.9873.3442.4860.0802.9161.7330.7361.0331.2490.069 Mapk11.4621.7681.3270.5950.8621.2570.4730.8261.6441.2900.602 Mef2a1.0940.5841.2490.1600.5441.2320.3170.9060.7150.525*0.039 Myd881.0720.4701.0200.5380.8631.3980.6070.2811.3580.2220.186 Plcb11.0040.0980.9950.3900.9551.3240.3700.1641.3130.3370.161 Tgfβ11.0270.2570.9970.6410.9180.6970.4660.3760.6980.3630.343Proinflammatory Tlr41.1510.3681.8131.1430.2071.1640.4500.2251.4060.7100.477 Cox21.0280.2701.1160.3190.6201.3110.3500.3361.6460.6380.099 Ym12.0222.4793.9534.3980.3713.7556.0460.9513.5982.9420.873CCR2/5 network Ccl21.0870.4717.6546.9980.0683.8312.4320.2353.1023.3280.181 Ccl31.6431.9884.6144.7740.2291.0421.4730.1451.4521.5650.193 Ccr21.0470.38421.3524.060.09610.4813.490.3684.7778.1510.234 Ccr51.0390.2802.1900.530*< 0.0011.1850.524*< 0.011.8191.2350.514Gene expression was measured by qPCR. Data are mean or standard deviation (Stdev), n = 5–6 mice/group*p < 0.05 and significant p values are offset from non-significant values
