The first goal of the analyses was to evaluate the effects of familial risk status on the likelihood that offspring would experience a psychiatric disorder during childhood or adolescence (Table 3 and 4). The second goal was to evaluate the effects of having an alcohol or drug dependent parent, or a parent with depression, on the likelihood that the offspring would experience an adverse psychiatric outcome without stratifying by risk category. Risk status and parental pathology are not synonymous in this sample. Some high-risk offspring from our multiplex pedigrees did not have an alcohol dependent parent (e.g., offspring of the nonalcoholic siblings of proband alcohol dependent individuals). The presence of a disorder at any annual visit during the developmental period of interest (adolescence or childhood) was coded as positive for that period. Odds ratios were adjusted for the varying number of assessments, offspring gender, and number of siblings in the family using the obtained coefficients from the logistic regression performed (SPSS version 14).
