OxoSQ infusion into the LDTg suppressed lever pressing for food pellets primarily during the first 60 min of the session. Unlike the cocaine group, the food pellet group acquired most of their pellet rewards during the first hour of each session, thus any suppression of behavior caused by OxoSQ did not appear to affect the measurement of BP, as it did for cocaine. Repeated measures ANOVAs for each time bin, with dose as the repeated measure, showed a significant main effect of treatment (Fig 3A) for the 30-min [F (2, 20) = 15.5, p = 0.0001] and 60-min time bins [F (2, 20) = 6.6, p = 0.006]. Bonferroni corrected pairwise mean comparisons for the 30-min bin showed that both OxoSQ 1 (p = 0.01) and 10 nmol (p = 0.002) caused a significant reduction in mean number of food pellets compared to aCSF (Fig 3A). The same comparisons for the 60-min bin showed that only OxoSQ 10 significantly affected lever pressing for food pellets compared to aCSF (p = 0.02). When all four time bins were included in the
