pellets compared to aCSF (Fig 3A). The same comparisons for the 60-min bin showed that only OxoSQ 10 significantly affected lever pressing for food pellets compared to aCSF (p = 0.02). When all four time bins were included in the analysis, the time bin by treatment interaction term was significant [F (6, 29) = 2.8, p = 0.03], and supported the largest effect of OxoSQ within the first hour (Fig 3A). Similar to the cocaine study however, the majority of rats in the food pellet study (7 out of 11; Fig 3A) attained a similar number of pellets by the second hour regardless of treatment. Repeated measures ANOVA on BPs showed a trend for a treatment effect [F (2, 20) = 2.6, p = 0.097] on the test day and no appreciable effect on baseline days (Fig 3B). The number of food pellets obtained for any of the time bins between baseline sessions and aCSF sessions did not significantly differ (Fig 3A inset). Similarly, the number of food pellets for any of the time bins between aCSF and CIC microinjection with OxoSQ 10 nmol was not statistically different (Fig 4B). The ratio of the inactive/active lever presses on average was
